Market Scenario

The Dental Bone Graft and Substitutes Market in Europe is expected to grow to US$ 435.66 Mn by 2030. With an estimated compounded annual growth rate of 6.9%, the market is analyzed to see a jump of 55% over the forecast period 2022-2030. The market for bone grafts and substitutes was valued at US$ 243.31 Mn in 2021.

In Europe, the incidence of oral cancer ranges from 5 to 10 cases per 100,000 people, according to the World Health Organization (WHO) (GLOBOCAN project). The prevalence of oral cancer is relatively higher in men, in older people, and among people of low education and low income. Around 20% of adults and more than 30% of seniors have advanced periodontal disease. Moreover, according to the Journal of the American Medical Association, from March to August 2020, the rate of weekly visits to a dentist was lower than in 2019. 

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End-users like hospitals and clinics have reported a decrease in patient visits as a result of the global lockdown limitations. Elective procedures were postponed or canceled during the COVID-19 pandemic, and the majority of elective surgeries were postponed or canceled. As a result, demand for oral/ dental surgery products such as bone grafts and substitutes has dropped dramatically. In addition, protracted factory closures by market players in several countries hindered device production. The majority of industries are having difficulty finding human resources to manufacture bone grafts and substitutes at manufacturing sites.

The dental bone grafts add volume and density to the jaw in areas where bone loss has occurred or where there is insufficient bone density. An increase in focus on R&D activities in bone grafts & their substitutes creates a lucrative growth opportunity for the market. Regulatory restrictions regarding the use of allograft materials have driven a shift towards the use of more synthetic grafting materials. Bone grafts are commonly used in dental surgeries and in dental implant procedures. 

MARKET DYNAMICS

Prominent factors influencing market growth during the forecast period include:

Drivers

Development of Biocompatible Synthetic Bone Grafts

Synthetic bone grafts are a viable alternative to autologous and allogeneic grafts due to their widespread availability, low cost, gradual biodegradation, higher compression strength, and lack of donor-site morbidity and virus transmission hazards. Calcium phosphate-based biomaterials and recombinant human bone morphological proteins are the most extensively utilized synthetic bone substitutes and biological factors. The development of biocompatible synthetic bone grafts is mainly due to an increase in demand for dental bone grafts in the market.

Increase in Demand for Dental Bone Grafts

The most prevalent application of bone grafting is in the placement of dental implants to repair a lost tooth's edentulous region. Bone grafts are expected to be used in around half of all dental implant operations currently conducted. Around 2.2 million bone graft surgeries are conducted globally each year, costing US$ 664 million by 2021. In Germany, there is a long-established insurance-based healthcare system of ‘sick funds’, which are not-for-profit organizations. Almost, 90% of the population belongs to one of these funds. The number of surgical procedures for treating bony defects is expected to climb approximately 13% yearly. However, the market is not free from hindrances.

Restraints 

Ethical Issues Related to Bone Grafting Procedures

Patients’ thoughts about the various bone graft materials available or their willingness to use these biomaterials in their procedures hamper the growth. Also, due to religious, ethical, and cultural reasons, the source of the bone graft may be undesirable to the patient. The bone transplants that generated the highest refusal percentage among respondents were allografts as 41% population declared that they would never accept this type of bone graft or would only do so if it was very necessary. However, though bone grafting has been a popular procedure across the globe, its high cost is one of the obstacles faced by the players in the market.

Higher Costs of Surgeries

Grafting surgery is one of the expensive treatments as multiple surgical procedures are needed. As per studies, this surgery is safe as bone tissue is extracted straight from various regions of the patient's body. The average cost of a dental bone graft ranges from $300 to $3,000 per graft.

Key Takeaways from the Report Based on Segments

• Based on the product, the autograft segment holds the highest share in the market in 2021 as it remains a reliable treatment option when structural stability is required. Autografts have been the standard for bone grafting in terms of healing as the graft is essentially the same tissue as the patient. As a result, the use of autografts in Europe will grow at the highest CAGR of 7.5% over the forecast period. Whereas the application of xenogeneic bone is limited due to the immune rejection induced by antigen. Moreover, various treatment types are available in the market owing to the increasing demand for dental bone grafts.
• On the basis of treatment type, the natural bone grafts like autographs, allografts, and xenografts are considered the old and gold standard in the bone grafting market, therefore occupying the largest share of 35.6% and 52.8% in 2021 and 2030, respectively. Whereas the synthetic bone graft substitutes segment is anticipated to grow at the highest CAGR of 7.5% over the forecast period as they are free from human pathogens and is also available in unlimited quantities and in different shapes and sizes. Furthermore, due to continuous research and development, these dental bone grafting find their place in various applications.
• In terms of application, the clinical applications segment dominated the market in 2021 as the main application of bone grafting is in the clinical field. They are used in clinical trials, bone reconstruction, clinical research, tissue engineering, microbiology, etc. hence, anticipated to grow at the highest CAGR of 7.7% over the forecast period. Moreover, due to increasing product launches and R&D funding in the coming years, various end users are adopting its usage.

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• By end-user, the contract manufacturing organizations segment holds the highest share of 43.5% in 2021. Contract manufacturing organizations help in jointly developing and manufacturing biologic products. Moreover, the academic and research organization segment is the least shareholding segment of the market as it occupies a minimal share of 3% in 2021 and 7.6% by 2030.
• Based on country, France is expected to grow with the highest CAGR of 7.8%, followed by the UK. The population of France is growing at 0.4% a year, the 60+ age group is expanding at a faster annual rate of 1.8%. The aging population typically requires more varied and complex dental treatments, such as removable prostheses, crowns, and implants. This will help France to have the highest growth rate in the market. Also, France has 2,533 dentist visits per year and UK has a low 1,662 visits per year. A high number of dentist visits creates a major opportunity for the country for dental bone grafts and substitutes market.

Competitive Landscape

The cumulative share of the major players is close to 52% in 2021. The key players in the Europe dental bone grafts and substitutes market are Ivoclar Vivadent, Zimmer Biomet, Dentsply Sirona, Nobel Biocare, Medtronic, BioHorizons IPH, Inc., ACE Surgical Supply Company, Geisclich Pharma AG, and Straumann Group among others. Through extensive research, it is found that big players have adopted various competitive strategies such as mergers & acquisitions in order to have a grip on an emerging market. Furthermore, leading companies are expanding their geographical boundaries by acquiring small brands and domestic companies.

Recent Developments by Key Players

• In January 2021, Dentsply Sirona acquired Datum Dental, a leading provider of the innovative OSSIX regenerative solutions portfolio. The acquisition of Datum Dental will open up significant opportunities for Dentsply Sirona within its Implants segment.
• The Straumann Group signed an investment agreement with the Shanghai Xin Zhuang Industrial Park (SHXIP) in March 2021 to establish its first campus in China comprising manufacturing, education, and innovation center at one site. With an investment of up to 1.2 billion Chinese yuan by 2029.
• Nobel Biocare's first synthetic membrane- Creos sent protect, is a significant addition to the creo regeneration range in March 2022. Nobel Biocare has expanded its regeneration product offering by partnering with a top-quality synthetic membrane production facility to launch a line of dense PTFE membranes.

Segmentation Overview 

Europe dental bone grafts and substitutes market is segmented based on product, treatment type, application, end-user, and region. The industry trends in the market are sub-divided into different categories in order to get a holistic view of the Europe marketplace. 

Following are the different segments of the Europe dental bone grafts and substitutes market:

By Product Segment 

• Xenograft
• Autograft
• Allograft
• Synthetic analysis

By Treatment Type segment 

• Natural bone grafts
  • Autologous bone grafts
  • Cancellous autografts
  • Cortical autografts
  • Allogeneic bone grafts
  • Cancellous allografts
  • Demineralized bone matrix (DBM)
• Synthetic bone graft substitutes
  • Calcium Sulphate
  • Calcium Phosphate Ceramics (CaP ceramics)
  • Tricalcium Phosphate (TCP)
  • Biphasic Calcium Phosphate (BCP)
  • Calcium Phosphate Cements (CPC)
  • Others
• Others

By Application segment 

• Research & Development
• Clinical Applications

By End User segment 

• Biopharmaceutical Companies
• Contract Research Organizations
• Contract Manufacturing Organizations
• Academic & Research Institutes

By Country segment 

• The UK
• Germany
• France
• Italy
• Spain
• Netherland
• Turkey
• Rest of Europe